Tadalafil is an orally administered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor.
Tadalafil’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the “weekend pill.” This longer half-life also is the basis of current investigation for tadalafil’s use in pulmonary arterial hypertension as a once-daily therapy.
Tadalafil tablets are indicated for the treatment of: erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), the signs and symptoms of BPH (ED/BPH).
The main advantage of Tadacip is that it acts quickly and its effect persists for a long time. You can buy Generic Cialis in advance and take it in the morning, while being sure that its action will persist for 36 hours. The effect occurs only 20 minutes after taking one tablet. At the same time, there are no restrictions on the intake of alcoholic beverages. At a time, you can take no more than one 20 mg tablet. Take it at least 20 minutes before sexual intercourse. The effect lasts for 36 hours. The effect of Tadacip manifests itself only with sexual arousal.
Tadalafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum.
This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Tadalafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.
This means that, with tadalafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, tadalafil should not cause an erection.
Mechanism of Action
Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.
This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.
All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Tadalafil.
Tell your doctor or pharmacist if you have any medical conditions.
Common tadalafil side effects may include: headache, flushing (warmth, redness, or tingly feeling), nausea, upset stomach, stuffy nose; or muscle pain, back pain, pain in your arms or legs.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.